Dose escalation studies and determination of dosing regimens
Increasing the dose in animals requires reformulation due to injection volume limitations. Viscosity and protein stability become problematic with higher doses when injection volume is limited. It is easy to conduct dose escalation studies in the PK-Eye™.
Bevacizumab dose escalation study in the PK-Eye™
Awwad et al, J Pharm Sci. 2015; 104 (10):3330-3342; Awwad et al, Macromol Biosci. 2018; 18 (2):1700255