Determination of in vitro in vivo correlations (IVIVCs)
The PK-Eye™ can also be used with other in vitro or computational permeability models to develop in vitro in vivo correlations (IVIVCs) for small molecular weight drugs that eliminate via the retina-choroid-sclera (RCS) pathway. This is analogous to strategies that are used to develop new dosage forms for oral and pulmonary administration.
In vitro in vivo correlation (IVIVCs) of novel dexamethasone thermally induced phase separation (TIPS) microparticles from the PK-Eye™
Awwad et al, Int J Pharm 2017; 522 (1-2):119-127